TISSUE: Predicting missing spatial gene expression with confidence
Several computational methods have been developed to augment spatially resolved single-cell transcriptomics to measure more genes. We developed TISSUE to build on these methods by providing confidence in these computational measurements and additional tools for performing data analysis.
Decoding Radiation-Induced Fibrosis: a computational approach to understanding the damage pathway
Computational modeling of radiation-induced lung fibrosis via the agent-based paradigm provides valuable insights into the initiation and progression of toxicity.
Contaminated landscapes – current use pesticides disperse from the valley bottom to the summit region
In this blog post Carsten Brühl from the institute for Environmental Sciences (iES) Landau at the RPTU in Germany is explaining the background of this first landscape level terrestrial pesticide exposure study.
A Detour for Prostate Cancer Cell Survival and Growth
Second generation AR antagonists, abiraterone and enzalutamide, induce aberrant HGF/MET and Wnt pathways leading to increased XPO1 expression and ribosomal biosynthesis in double-null prostate cancer (DNPC). However, treatment with XPO1 and ribosomal inhibitors showed an improved antitumor response.
Are we prepared for the next pandemic? New tools for measurement and assessment
Studies show that standard preparedness measures do not predict COVID-19 outcomes, suggesting new measures are needed. But evaluating metrics is more than prediction. Measurement science points the way to tools that capture operational capabilities , including coordination and decisionmaking.
Bridging the Gap: Potential Impact of Digital Health Interventions on Simultaneous Hypertension and Mental Health care
Hypertension and mental health challenges often co-occur but current care pathways lack simultaneous physical and mental health support. Here we describe the rationale for a feasibility RCT looking at the impact of a digital health tool (Holly Health) in a primary care setting.